# STOCKHOLM 1.0 #=GF ID 1.10.510.10/FF/001216 #=GF DE Leucine-rich repeat kinase 2 #=GF AC 1.10.510.10/FF/001216 #=GF TP FunFam #=GF DR CATH: v4.3 #=GF DR DOPS: 79.762 #=GS Q54WS5/1346-1631 AC Q54WS5 #=GS Q54WS5/1346-1631 OS Dictyostelium discoideum #=GS Q54WS5/1346-1631 DE Probable serine/threonine-protein kinase roco6 #=GS Q54WS5/1346-1631 DR ORG; Eukaryota; Dictyosteliales; Dictyosteliaceae; Dictyostelium; Dictyostelium discoideum; #=GS Q54WS5/1346-1631 DR EC; 2.7.11.1; #=GS A9VD08/309-624 AC A9VD08 #=GS A9VD08/309-624 OS Monosiga brevicollis #=GS A9VD08/309-624 DE Predicted protein #=GS A9VD08/309-624 DR ORG; Eukaryota; Choanoflagellida; Salpingoecidae; Monosiga; Monosiga brevicollis; #=GS F8W598/1849-2135 AC F8W598 #=GS F8W598/1849-2135 OS Danio rerio #=GS F8W598/1849-2135 DE Leucine-rich repeat kinase 2 #=GS F8W598/1849-2135 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Actinopterygii; Actinopteri; Neopterygii; Teleostei; Otomorpha; Ostariophysi; Cypriniphysae; Cypriniformes; Cyprinoidei; Cyprinidae; Danio; Danio rerio; #=GS Q6DF89/13-300 AC Q6DF89 #=GS Q6DF89/13-300 OS Xenopus laevis #=GS Q6DF89/13-300 DE LOC445832 protein #=GS Q6DF89/13-300 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus; Xenopus laevis; #=GS F0ZZA9/1265-1555 AC F0ZZA9 #=GS F0ZZA9/1265-1555 OS Dictyostelium purpureum #=GS F0ZZA9/1265-1555 DE Roco6, ROCO family protein #=GS F0ZZA9/1265-1555 DR ORG; Eukaryota; Dictyosteliales; Dictyosteliaceae; Dictyostelium; Dictyostelium purpureum; #=GS F7EB41/1559-1838 AC F7EB41 #=GS F7EB41/1559-1838 OS Ornithorhynchus anatinus #=GS F7EB41/1559-1838 DE Uncharacterized protein #=GS F7EB41/1559-1838 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus; Ornithorhynchus anatinus; #=GS B0BML0/90-372 AC B0BML0 #=GS B0BML0/90-372 OS Xenopus tropicalis #=GS B0BML0/90-372 DE LOC100145062 protein #=GS B0BML0/90-372 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana; Xenopus tropicalis; #=GS F6URV2/1855-2130 AC F6URV2 #=GS F6URV2/1855-2130 OS Xenopus tropicalis #=GS F6URV2/1855-2130 DE Leucine-rich repeat kinase 2 #=GS F6URV2/1855-2130 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana; Xenopus tropicalis; #=GS A0A1L8GZ36/1860-2146 AC A0A1L8GZ36 #=GS A0A1L8GZ36/1860-2146 OS Xenopus laevis #=GS A0A1L8GZ36/1860-2146 DE Uncharacterized protein #=GS A0A1L8GZ36/1860-2146 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus; Xenopus laevis; #=GF SQ 9 Q54WS5/1346-1631 YKYGD-----------LLEIEFESP--KLIGRGASGKIYRANLNDTMVAVKQL-----EVVGEDAP-RIFSEFRREIHVMSDLKHSNVVNLLG-------FTLSPFTMVMEYIDCGDLHKFLHSPIGDQLNGNWALILKLALDIAKGMEFLHSVTPPLLHRDLKSPNVLL-SMKD------------------------GVYTAKVGDFGLSS---RMFIQALKHKLRNFPVGNITWVAPEILREEE-YTVKSDVYAFGLILHELLTR-KHPYREFNYSMVSLQEDAIKNGLRPTISPSYTQTVTGHEYCGLIQDCWDSDIDRRPTFNKIVKRIKQIIG----RDV---------- A9VD08/309-624 M--SDSMLEGLTTFSLIERNELLDL--HLIGRGSFGAVYRATWQGHDVAVKQLVRSSLQCTDADSA----PEFDAELKVLSELRHPNIVQLFGVSHTYDESGKYAVWLCMEYATHGSLYNLLYT---SEDIYDLRIALQWAQGIADGMEYLHAHG--LIHYDLKSPNVLL-SLEPSLMGRSLSASMSEVEPGEHDDFSLDALVPKICDFGSALRHDACQTARGF--------GTFLWMAPECMQNKEPPSFPADVYSFAMILYELFGR-RRPFAGMELPAV-IVTVALR-HERPELD----GIHPW--IAEVISECWQPQASERWTFGRVSKHLRAMAF----SDEDNASL----- F8W598/1849-2135 DQPSSTILDP-------EQLEMELTAEYMLGDGGFGSVYKAVYKNEEVAVKIFNKH-------ASALYVHRLVRQELAVLGRLCHPSLVGLLA-------AGCNPHILVMELAPYGSLDSLFER---ENGSLSRKLQHRIALHVADGLKYLHSSM--IIYRDLKPHNVLLFNLKTD-----------------------AEIVAKITDYGIAQYCCSMGVRSSE--------GTPGFRAPEVARGNVIYNVQADVYSFGLLLYDLLTYGERISDGMKFPSE-FDEVAVQ-GKLPDPVKDY-GCSPWPEIESLMRECMRENPQDRPTSAQVFDRLNSAEMLCLMRELN--------- Q6DF89/13-300 ----NIMLNA-------EELEFDQAPEFLLGDGGFGSVYRASYKGEDVAVKIFNKH-------TSS----RLLRQELTVLSHLHHPSLVYLLA-------AGVHPRMLVMELAPKGSLDHLLQQ---DSASLTRTLQHRIALHVADGLRYLHSAM--IIYRDLKPHNVLLFTLYPN-----------------------SAIIAKIADYGIAQYCCRMGIKTSE--------GTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTGGARMVEGLKFPNE-FDELAIH-GRLPDPVKEY-NCAPWPEVEVLIKKCLKENPQQRPTSVTVYEILNSAELLCLMRNHVIFSMLTAEC F0ZZA9/1265-1555 I--GNNKQDQF----IIGEVEFDSP--KLIGRGASGKIYRANLGDTMVAVKQL-----EVVGEDAP-RIFSDFRREIHVMSDLKHPNVVNLLG-------FTLNPFTMVMEYIDCGDLHKFLHSQIGDILNGNWALILKLALDIAKGMDFLHSVTPPLLHRDLKSPNVLL-SMKN------------------------GVYHAKVGDFGLSS---RMFIQALKHKLRNFPVGNITWVAPEILREEE-YTVKSDVYAFGLILHELMTR-KHPYREFNYQMVSLQEEAIKSGLRPTIAPQYTQTVTGHEYCALIRDCWDSDIDRRPTFNKIVKRIKQIIG----RDV---------- F7EB41/1559-1838 -------VEN-------EEVVYPSRLGQALGTEGTASIQRCLWRYEEGAIVHGQRH-------DEF----FPLSQELVVLCHLHHPSLISLLA-------AGIRPRMLVMELASKGSLDRLLQQ---DKSSLTRTLQHRIALHVADGLRYLHSAM--IIYRDLKPHNVLLFTLYPN-----------------------AAVIAKIADYGIAQYCCRMGIKTSE--------GTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTAGGRIVEGLKFPNE-FDEIALQ-GRLPDPVKEY-GCAPWPEVEKLIKKCLKENPQERPTSAQMYEILNSAELICLMRNITIPTT----- B0BML0/90-372 ----NIMLNA-------EELEFDQAPEFLLGDGGFGSVYRASYKGEDVAVKIFNKH-------TSS----RLLRQELTVLSHLHHPSLVCLLA-------AGVHPRMLVMELAPKGSLDHLLQQ---DCASLTRTLQHRIALHVADGLRYLHSAM--IIYRDLKPHNVLLFTLYPN-----------------------SAIIAKIADYGIAQYCCRMGIKTSE--------GTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTGGARMVEGLKFPNE-FDELAIH-GRLPDPVKEY-NCAPWPEVEVLIKKCLKENPQQRPTSATVYEILNSAELLCLMRNIVIFSM----- F6URV2/1855-2130 -----IMLNA-------EELEFDQAPEFLLGDGGFGSVYRASYKGEDVAVKIFNKH-------TSS----RLLRQELTVLSHLHHPSLVCLLA-------AGVHPRMLVMELAPKGSLDHLLQQ---DCASLTRTLQHRIALHVADGLRYLHSAM--IIYRDLKPHNVLLFTLYPN-----------------------SAIIAKIADYGIAQYCCRMGIKTSE--------GTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTGGARMVEGLKFPNE-FDELAIH-GRLPDPVKEY-NCAPWPEVEVLIKKCLKENPQQRPTSATVYEILNSAELLCLMRN----------- A0A1L8GZ36/1860-2146 -----IMLNA-------EELEFDQAPEFLLGDGGFGSVYRASYKGEDVAVKIFNKH-------TSS----RLLRQELTVLSHLHHPSLVYLLA-------AGVHPRMLVMELAPKGSLDHLLQQ---DSASLTRTLQHRIALHVADGLRYLHSAM--IIYRDLKPHNVLLFTLYPN-----------------------SAIIAKIADYGIAQYCCRMGIKTSE--------GTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTGGARMVEGLKFPNE-FDELAIH-GRLPDPVKEY-NCAPWPEVEVLIKKCLKENPQQRPTSVTVYEILNSAELLCLMRNHVIFSMLTAEC #=GC scorecons 00012223320000000564754331136694754747787344444798744232000000045400003355596397649497558397500000004634733769956439694467540006234344474464964696964799744006666999559999257342000000000000000000000004544797497956423256364444000000009644549995475542653569996977697666742364346556534054639650634954433604446536433784594445444969444635365444312226521101100000 #=GC scorecons_70 ____________________*_______*_*_*__*_****______****________________________**_***_*_**__*_**____________*__****____*_*__**_____*_______*____**_**_**_****_____******__****__*______________________________***_***_*_____*_*____________**____***__*____*___********_******___*___*_________*_*___*__*__________*______**__*_______*_*___*___*_________*____________ #=GC scorecons_80 ____________________*_________*_*__*__***______****________________________*__*___*_**__*_**____________*____**____*_*___*_____________*____*___*_*__****________***__****_________________________________***_***______________________*_____***__*_________***_***_**_______________________*______*_________________**__*_______*_*______________________________ #=GC scorecons_90 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