# STOCKHOLM 1.0
#=GF ID 1.10.268.10/FF/000013
#=GF DE DNA topoisomerase 2
#=GF AC 1.10.268.10/FF/000013
#=GF TP FunFam
#=GF DR CATH: v4.3
#=GF DR DOPS: 55.170
#=GS P15348/997-1187                 AC P15348
#=GS P15348/997-1187                 OS Drosophila melanogaster
#=GS P15348/997-1187                 DE DNA topoisomerase 2
#=GS P15348/997-1187                 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila melanogaster; 
#=GS P15348/997-1187                 DR GO; GO:0000070; GO:0000182; GO:0000278; GO:0000400; GO:0000819; GO:0003677; GO:0003682; GO:0003696; GO:0003729; GO:0003918; GO:0005515; GO:0005634; GO:0005694; GO:0006265; GO:0006342; GO:0007060; GO:0007076; GO:0008623; GO:0030261; GO:0051310; GO:0051321; 
#=GS P15348/997-1187                 DR EC; 5.6.2.3; 
#=GS Q7PWM2/996-1097_1131-1194       AC Q7PWM2
#=GS Q7PWM2/996-1097_1131-1194       OS Anopheles gambiae
#=GS Q7PWM2/996-1097_1131-1194       DE DNA topoisomerase 2
#=GS Q7PWM2/996-1097_1131-1194       DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Cellia; Anopheles gambiae; 
#=GS A0A1S4GZL9/1022-1123_1157-1220  AC A0A1S4GZL9
#=GS A0A1S4GZL9/1022-1123_1157-1220  OS Anopheles gambiae
#=GS A0A1S4GZL9/1022-1123_1157-1220  DE DNA topoisomerase 2
#=GS A0A1S4GZL9/1022-1123_1157-1220  DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Cellia; Anopheles gambiae; 
#=GS D6WF48/1029-1215                AC D6WF48
#=GS D6WF48/1029-1215                OS Tribolium castaneum
#=GS D6WF48/1029-1215                DE DNA topoisomerase 2
#=GS D6WF48/1029-1215                DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Coleoptera; Polyphaga; Cucujiformia; Tenebrionoidea; Tenebrionidae; Tribolium; Tribolium castaneum; 
#=GS B4I5V4/997-1186                 AC B4I5V4
#=GS B4I5V4/997-1186                 OS Drosophila sechellia
#=GS B4I5V4/997-1186                 DE DNA topoisomerase 2
#=GS B4I5V4/997-1186                 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila sechellia; 
#=GS B3NM53/997-1186                 AC B3NM53
#=GS B3NM53/997-1186                 OS Drosophila erecta
#=GS B3NM53/997-1186                 DE DNA topoisomerase 2
#=GS B3NM53/997-1186                 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila erecta; 
#=GS B4PAY8/997-1186                 AC B4PAY8
#=GS B4PAY8/997-1186                 OS Drosophila yakuba
#=GS B4PAY8/997-1186                 DE DNA topoisomerase 2
#=GS B4PAY8/997-1186                 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila yakuba; 
#=GS A0A0J9R4V1/997-1186             AC A0A0J9R4V1
#=GS A0A0J9R4V1/997-1186             OS Drosophila simulans
#=GS A0A0J9R4V1/997-1186             DE DNA topoisomerase 2
#=GS A0A0J9R4V1/997-1186             DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila simulans; 
#=GF SQ 8
P15348/997-1187                         -AIDILKEYYKLRREYYARRRDFLVGQLTAQADRLSDQARFILEKCEKKLVVENKQRKAMCDELLKRGYRPDPVKEWQRRIKMEDAEQADEEDEEEEEAAPSVSSKAKKEKEVDPEKAFKKLTDVKKFDYLLGMSMWMLTEEKKNELLKQRDTKLSELESLRKKTPEMLWLDDLDALESKLNEVEEKERAEE
Q7PWM2/996-1097_1131-1194               -ANEIFMEFYTVRLDFYGKRRAYLLGMLQAEADSLSDKARFIMEKCNGTLVVENKKRKALIDELIKRGYRADPIQEWKRRVQTNDEEEEDQQGEGEEE------------------------EEQEDFNYLLGMSMWMLTEERKNEILKQRDQKLAELKSLEAKTVQGLWMDDLDALSRKLDEVEEKERLD-
A0A1S4GZL9/1022-1123_1157-1220          -ANEIFMEFYTVRLDFYGKRRAYLLGMLQAEADSLSDKARFIMEKCNGTLVVENKKRKALIDELIKRGYRADPIQEWKRRVQTNDEEEEDQQGEGEEE------------------------EEQEDFNYLLGMSMWMLTEERKNEILKQRDQKLAELKSLEAKTVQGLWMDDLDALSRKLDEVEEKERLD-
D6WF48/1029-1215                        SVTDILKDYYKLRLTMYQKRKDYLEGMLKAEASKLSNQARFIMEKCDRTLVVENKKRKVIIDELIKRGYEPDPVKDWKQRVATED---GDEEAPAEEEEAPATEQTTK--KPVDPEKAFQNSTDVQKFDYLLGMSMWMLTEEKKNELLRQRDIKLQELETLKKKTHCDLWREDLDAFMEKLDEVEEKERNDE
B4I5V4/997-1186                         -AIDILKEFYKLRREYYARRRDFLVGQLTAQADRLSDQARFILEKCEKKLVVENKQRKAMCDELLKRGYRPDPVKEWQRRIKMEDAEQADEEDDEEEEAAPSVSSKAKKEKEADPEKAFKKLTDVKKFDYLLGMSMWMLTEERKNELLKQRDTKLSELENLRKKTPEMLWLDDLDALESKLNEVEQKERVE-
B3NM53/997-1186                         -AIDILKEFYELRREYYARRKDFLVGQLTAQADRLSDQARFIVEKCDKKLVVENKQRKAMCDELLKRGYRPDPVKEWQRRIKMEDAEPANEEDDEEEEAAPSASSKVKKEKDVDPDKAFKKLTDVKKFDYLLGMSMWMLTEEKKNELLKQRDAKLSELENLRKKTPELLWLDDLDALEAKLNEVEEKERLE-
B4PAY8/997-1186                         -AVDILKEFYQLRREYYARRKDFLVGQLTAQADRLSDQARFILEKCEKKLVVENKQRKAMCDELLKRGYRPDPVKEWQRRIKMEDAEPANEEDDEEEEAAPSVSSKVKKEKEVDPEKAFKKLTDVKKFDYLLGMSMWMLTEEKKNELLKQRDAKLAELENLRKKTPELLWLDDLDALESKLNEVEEKERLE-
A0A0J9R4V1/997-1186                     -AIDILKEFYKLRREYYARRRDFLVGQLTAQADRLSDQARFILEKCEKKLVVENKQRKAMCDELLKRGYRPDPVKEWQRRIKMEDAEPADEEDDEEEEAAPSVSSKAKKEKEADPEKAFKKLTDVKKFDYLLGMSMWMLTEEKKNELLKQRDTKLSELENLRKKTPEMLWLDDLDALESKLNEVEQKERVE-
#=GC scorecons                          074796577946945594697579494949697499769999699954599999969975499969999769976796796456936247664549992332122213113123333332225745596999999999999969996979993994996595599443994799997439969997999460
#=GC scorecons_70                       _*_***_***_**___*_***_**_*_*_*_**_********_***___******_***__***_*****_******_***___*____***___***_________________________*___*************************_**_**__*__**___**_******__**_*******_*_
#=GC scorecons_80                       _*__*__***__*___*__*__**_*_*_*_*__***_****_***___******_***__***_****__**__**_**____*____*_____***_____________________________*_*************_***_*****_**_**__*__**___**_******__**_*******___
#=GC scorecons_90                       ____*____*__*___*__*___*_*_*_*_*__**__****_***___******_**___***_****__**___*__*____*__________***_____________________________*_*************_***_*_***_**_**__*__**___**__****___**_***_***___
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