# STOCKHOLM 1.0 #=GF ID 1.10.10.60/FF/000354 #=GF DE Double homeobox protein 4 #=GF AC 1.10.10.60/FF/000354 #=GF TP FunFam #=GF DR CATH: v4.3 #=GF DR DOPS: 68.777 #=GS Q9UBX2/8-85 AC Q9UBX2 #=GS Q9UBX2/8-85 OS Homo sapiens #=GS Q9UBX2/8-85 DE Double homeobox protein 4 #=GS Q9UBX2/8-85 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; #=GS Q9UBX2/8-85 DR GO; GO:0000976; GO:0000978; GO:0001228; GO:0005515; GO:0005634; GO:0005654; GO:0005730; GO:0005794; GO:0005829; GO:0006915; GO:0008285; GO:0031965; GO:0045944; GO:0070317; GO:1990837; #=GS O43812/19-86 AC O43812 #=GS O43812/19-86 OS Homo sapiens #=GS O43812/19-86 DE Double homeobox protein 1 #=GS O43812/19-86 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; #=GS O43812/19-86 DR GO; GO:0000977; GO:0001228; GO:0005515; GO:0005634; GO:0006366; GO:0045944; #=GS Q6RFH8/17-81 AC Q6RFH8 #=GS Q6RFH8/17-81 OS Homo sapiens #=GS Q6RFH8/17-81 DE Double homeobox protein 4C #=GS Q6RFH8/17-81 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; #=GS Q6RFH8/17-81 DR GO; GO:0000976; GO:0005515; GO:0005634; GO:0008283; GO:0010468; GO:0045944; #=GS C3U3A0/8-85 AC C3U3A0 #=GS C3U3A0/8-85 OS Homo sapiens #=GS C3U3A0/8-85 DE DUX4 #=GS C3U3A0/8-85 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; #=GS C3U3A0/8-85 DR GO; GO:0005634; GO:0005730; GO:0005794; GO:0005829; #=GS A6NLW8/15-71 AC A6NLW8 #=GS A6NLW8/15-71 OS Homo sapiens #=GS A6NLW8/15-71 DE Double homeobox protein A #=GS A6NLW8/15-71 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; #=GS A6NLW8/15-71 DR GO; GO:0000981; #=GS P0CJ90/8-85 AC P0CJ90 #=GS P0CJ90/8-85 OS Homo sapiens #=GS P0CJ90/8-85 DE Double homeobox protein 4-like protein 7 #=GS P0CJ90/8-85 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; #=GS P0CJ90/8-85 DR GO; GO:0000981; #=GS P0CJ89/8-85 AC P0CJ89 #=GS P0CJ89/8-85 OS Homo sapiens #=GS P0CJ89/8-85 DE Double homeobox protein 4-like protein 6 #=GS P0CJ89/8-85 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; #=GS P0CJ89/8-85 DR GO; GO:0000981; #=GS P0CJ88/8-85 AC P0CJ88 #=GS P0CJ88/8-85 OS Homo sapiens #=GS P0CJ88/8-85 DE Double homeobox protein 4-like protein 5 #=GS P0CJ88/8-85 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; #=GS P0CJ88/8-85 DR GO; GO:0000981; #=GS P0CJ86/8-85 AC P0CJ86 #=GS P0CJ86/8-85 OS Homo sapiens #=GS P0CJ86/8-85 DE Double homeobox protein 4-like protein 3 #=GS P0CJ86/8-85 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; #=GS P0CJ86/8-85 DR GO; GO:0000981; #=GS P0CJ85/8-85 AC P0CJ85 #=GS P0CJ85/8-85 OS Homo sapiens #=GS P0CJ85/8-85 DE Double homeobox protein 4-like protein 2 #=GS P0CJ85/8-85 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; #=GS P0CJ85/8-85 DR GO; GO:0000981; #=GS P0CJ87/8-85 AC P0CJ87 #=GS P0CJ87/8-85 OS Homo sapiens #=GS P0CJ87/8-85 DE Double homeobox protein 4-like protein 4 #=GS P0CJ87/8-85 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; #=GS P0CJ87/8-85 DR GO; GO:0000981; #=GS A0A384NPT7/46-112 AC A0A384NPT7 #=GS A0A384NPT7/46-112 OS Homo sapiens #=GS A0A384NPT7/46-112 DE Epididymis secretory sperm binding protein #=GS A0A384NPT7/46-112 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; #=GS Q96PT3/46-112 AC Q96PT3 #=GS Q96PT3/46-112 OS Homo sapiens #=GS Q96PT3/46-112 DE Double homeobox protein 5 #=GS Q96PT3/46-112 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; #=GS A0A1B0GW55/8-85 AC A0A1B0GW55 #=GS A0A1B0GW55/8-85 OS Homo sapiens #=GS A0A1B0GW55/8-85 DE Uncharacterized protein #=GS A0A1B0GW55/8-85 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; #=GS Q14333/479-543 AC Q14333 #=GS Q14333/479-543 OS Homo sapiens #=GS Q14333/479-543 DE Facioscapulohumeral muscular dystrophy #=GS Q14333/479-543 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; #=GS C3U395/282-346 AC C3U395 #=GS C3U395/282-346 OS Homo sapiens #=GS C3U395/282-346 DE DUX4 #=GS C3U395/282-346 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; #=GS A0A0D9SDP3/11-85 AC A0A0D9SDP3 #=GS A0A0D9SDP3/11-85 OS Chlorocebus sabaeus #=GS A0A0D9SDP3/11-85 DE Double homeobox 4 #=GS A0A0D9SDP3/11-85 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Chlorocebus; Chlorocebus sabaeus; #=GS G1RIZ9/16-71 AC G1RIZ9 #=GS G1RIZ9/16-71 OS Nomascus leucogenys #=GS G1RIZ9/16-71 DE Uncharacterized protein #=GS G1RIZ9/16-71 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hylobatidae; Nomascus; Nomascus leucogenys; #=GS H2P0B9/15-71 AC H2P0B9 #=GS H2P0B9/15-71 OS Pongo abelii #=GS H2P0B9/15-71 DE DUXA isoform 1 #=GS H2P0B9/15-71 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Ponginae; Pongo; Pongo abelii; #=GS A0A2R9BXJ4/15-71 AC A0A2R9BXJ4 #=GS A0A2R9BXJ4/15-71 OS Pan paniscus #=GS A0A2R9BXJ4/15-71 DE Uncharacterized protein #=GS A0A2R9BXJ4/15-71 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Pan; Pan paniscus; #=GS G3QSA4/15-71 AC G3QSA4 #=GS G3QSA4/15-71 OS Gorilla gorilla gorilla #=GS G3QSA4/15-71 DE Double homeobox A #=GS G3QSA4/15-71 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Gorilla; Gorilla gorilla; Gorilla gorilla gorilla; #=GS A0A2K5UFI0/12-75 AC A0A2K5UFI0 #=GS A0A2K5UFI0/12-75 OS Macaca fascicularis #=GS A0A2K5UFI0/12-75 DE Uncharacterized protein #=GS A0A2K5UFI0/12-75 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Macaca; Macaca fascicularis; #=GS A0A2I3LWD9/19-82 AC A0A2I3LWD9 #=GS A0A2I3LWD9/19-82 OS Papio anubis #=GS A0A2I3LWD9/19-82 DE Uncharacterized protein #=GS A0A2I3LWD9/19-82 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Papio; Papio anubis; #=GS H2R5U0/15-71 AC H2R5U0 #=GS H2R5U0/15-71 OS Pan troglodytes #=GS H2R5U0/15-71 DE DUXA isoform 1 #=GS H2R5U0/15-71 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Pan; Pan troglodytes; #=GS P79358/1-63 AC P79358 #=GS P79358/1-63 OS Macaca mulatta #=GS P79358/1-63 DE Putative homeobox protein #=GS P79358/1-63 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Macaca; Macaca mulatta; #=GS A0A2I3RUM0/8-85 AC A0A2I3RUM0 #=GS A0A2I3RUM0/8-85 OS Pan troglodytes #=GS A0A2I3RUM0/8-85 DE Uncharacterized protein #=GS A0A2I3RUM0/8-85 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Pan; Pan troglodytes; #=GS A0A2I3H1Y0/17-81 AC A0A2I3H1Y0 #=GS A0A2I3H1Y0/17-81 OS Nomascus leucogenys #=GS A0A2I3H1Y0/17-81 DE Uncharacterized protein #=GS A0A2I3H1Y0/17-81 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hylobatidae; Nomascus; Nomascus leucogenys; #=GS A0A2I3HH44/17-81 AC A0A2I3HH44 #=GS A0A2I3HH44/17-81 OS Nomascus leucogenys #=GS A0A2I3HH44/17-81 DE Uncharacterized protein #=GS A0A2I3HH44/17-81 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hylobatidae; Nomascus; Nomascus leucogenys; #=GS A0A2I3GZW3/17-81 AC A0A2I3GZW3 #=GS A0A2I3GZW3/17-81 OS Nomascus leucogenys #=GS A0A2I3GZW3/17-81 DE Uncharacterized protein #=GS A0A2I3GZW3/17-81 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hylobatidae; Nomascus; Nomascus leucogenys; #=GS A0A2I3HPF8/17-81 AC A0A2I3HPF8 #=GS A0A2I3HPF8/17-81 OS Nomascus leucogenys #=GS A0A2I3HPF8/17-81 DE Uncharacterized protein #=GS A0A2I3HPF8/17-81 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hylobatidae; Nomascus; Nomascus leucogenys; #=GS A0A2I3HHM9/17-81 AC A0A2I3HHM9 #=GS A0A2I3HHM9/17-81 OS Nomascus leucogenys #=GS A0A2I3HHM9/17-81 DE Uncharacterized protein #=GS A0A2I3HHM9/17-81 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hylobatidae; Nomascus; Nomascus leucogenys; #=GS H2PEZ9/17-81 AC H2PEZ9 #=GS H2PEZ9/17-81 OS Pongo abelii #=GS H2PEZ9/17-81 DE Double homeobox 4 #=GS H2PEZ9/17-81 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Ponginae; Pongo; Pongo abelii; #=GS A0A2I3GWD9/17-81 AC A0A2I3GWD9 #=GS A0A2I3GWD9/17-81 OS Nomascus leucogenys #=GS A0A2I3GWD9/17-81 DE Uncharacterized protein #=GS A0A2I3GWD9/17-81 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hylobatidae; Nomascus; Nomascus leucogenys; #=GF SQ 33 Q9UBX2/8-85 DSTLPAEARGRGRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSRQLRQHRRESRPW- O43812/19-86 -----------GRRMILLSTPSQSDALRACFERNLYPGIATKEELAQGIDIPEPRVQIWFQNERSCQLRQHRRQSRPWP Q6RFH8/17-81 ---------GRGRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSRQLRQHRRE----- C3U3A0/8-85 DSTLPAEARGRGRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSRQLRQHRRESRPW- A6NLW8/15-71 -----------HRRCRTKFTEEQLKILINTFNQKPYPGYATKQKLALEINTEESRIQIWFQNRRARHG----------- P0CJ90/8-85 DSTLPAEARGRGRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSRQLRQHRRESRPW- P0CJ89/8-85 DSTLPAEARGRGRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSRQLRQHRRESRPW- P0CJ88/8-85 DSTLPAEARGRGRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSRQLRQHRRESRPW- P0CJ86/8-85 DSTLPAEARGRGRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSRQLRQHRRESRPW- P0CJ85/8-85 DSTLPAEARGRGRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSRQLRQHRRESRPW- P0CJ87/8-85 DSTLPAEARGRGRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSRQLRQHRRESRPW- A0A384NPT7/46-112 -----------GRRMILLSTPSQSDALRACFERNLYPGIATKEELAQGIDIPEPRVQIWFQNERSCQLRQHRRQSRPW- Q96PT3/46-112 -----------GRRMILLSTPSQSDALRACFERNLYPGIATKEELAQGIDIPEPRVQIWFQNERSCQLRQHRRQSRPW- A0A1B0GW55/8-85 DSTLPAEARGRGRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSRQLRQHRRESRPW- Q14333/479-543 ---------GRGRPRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSRQLRQHRRE----- C3U395/282-346 ---------GRGRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSRQLRQHRRE----- A0A0D9SDP3/11-85 ---LPAEARGRGRRRRLAWTPSQREALRACFERNPYPGIATREELARAIGMPEPRVQIWFQNERSRQLRQHRRESRPW- G1RIZ9/16-71 ------------RRCRTKFTEDQLKILINTFNQKPYPGYATKQKLALEINTEESRIQIWFQNRRARHG----------- H2P0B9/15-71 -----------HRRCRTKFTEEQLKILIDTFNQKPYPGYATKQKLALEINTEESRIQIWFQNRRARHG----------- A0A2R9BXJ4/15-71 -----------HRRCRTKFTEEQLKILINTFNQKPYPGYATKQKLALEINTEESRIQIWFQNRRARHG----------- G3QSA4/15-71 -----------HRRCRTKFTEEQLKILINTFNQKPYPGYATKQKLALEINTEESRIQIWFQNRRARHG----------- A0A2K5UFI0/12-75 -----------GRRRRLVWTPSQREALRACFERNPYPGIATREELAQAIGIPEPRVQIWFQNERSRPLRQHRRES---- A0A2I3LWD9/19-82 -----------GRRRRLVWTPSQREALRACFERNPYPGIATREELAQDIGIPEPRVQIWFQNERSRQLRQHRRES---- H2R5U0/15-71 -----------HRRCRTKFTEEQLKILINTFNQKPYPGYATKQKLALEINTEESRIQIWFQNRRARHG----------- P79358/1-63 ------------RRRRLVWTPSQREALRACFERNPYPGIATREELAQAIGIPEPRVQIWFQNERSRPLRQHRRES---- A0A2I3RUM0/8-85 DSTLPAEARGRGRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSRQLRQHRRESRPW- A0A2I3H1Y0/17-81 ---------GRGRRTRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGVPEPRVQIWFQNERSRQLRQHRRE----- A0A2I3HH44/17-81 ---------GRGRRRRLVWTPSQSEALRACFERNPYPGIATRELLAQAIGVPEPRVQIWFQNERSRQLRQHRRE----- A0A2I3GZW3/17-81 ---------GRGRRRRLVWTPSQIEALRACFERNPYPGIATRERLAQAIGVPEPRVQIWFQNERSRQLRQHRRE----- A0A2I3HPF8/17-81 ---------GRGRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGVPEPRVQIWFQNERSRQLRQHRRE----- A0A2I3HHM9/17-81 ---------GRGRWRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGVPEPRVQIWFQNERSRQLRQHRRE----- H2PEZ9/17-81 ---------GRGRRRRLVWTPSQSEALRACFERNPYPGIATREGLAQAIGVPEPRVQIWFQNERSRQLRQHRRE----- A0A2I3GWD9/17-81 ---------GRGRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGVPEPRVQIWFQNERSRQLRQHRRE----- #=GC scorecons 0000000002259847645955946695669666799959976599559555969799999969676544444311110 #=GC scorecons_70 ____________**_*___*__*__**___********_****_**__*___***************____________ #=GC scorecons_80 ____________**_*___*__*___*___*___****_**___**__*___*_********_*_*_____________ #=GC scorecons_90 ____________**_____*__*___*___*____***_**___**__*___*_*_******_*_______________ //