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CATH Superfamily 1.10.10.10

Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 9: LexA repressor

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Repressor LexA. [EC: 3.4.21.88]
Hydrolysis of Ala-|-Gly bond in repressor LexA.
  • In the presence of single-stranded DNA, the RecA protein interacts with LexA causing an autocatalytic cleavage which disrupts the DNA- binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
  • The activity was previously attributed to the RecA protein (formerly EC 3.4.99.37).
  • Belongs to peptidase family S24.
 52470 A0A023Z6W3 A0A023Z6W3 A0A023Z6W3 A0A023Z6W3 A0A023Z6W3 A0A023Z6W3 A0A023Z6W3 A0A023Z6W3 A0A023Z6W3 A0A023Z6W3
(52460 more...)