# STOCKHOLM 1.0
#=GF ID 1.10.10.10/FF/000655
#=GF DE Type 2 DNA topoisomerase 6 subunit A
#=GF AC 1.10.10.10/FF/000655
#=GF TP FunFam
#=GF DR CATH: v4.3
#=GF DR DOPS: 94.805
#=GS 2zbkG01/1-158     AC O05208
#=GS 2zbkG01/1-158     OS Saccharolobus shibatae
#=GS 2zbkG01/1-158     DE Type 2 DNA topoisomerase 6 subunit A
#=GS 2zbkG01/1-158     DR CATH; 2zbk; G:10-158; 
#=GS 2zbkG01/1-158     DR ORG; Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae; Saccharolobus; Saccharolobus shibatae; 
#=GS 2zbkG01/1-158     DR GO; GO:0005515; 
#=GS 2zbkG01/1-158     DR EC; 5.6.2.3; 
#=GS 2q2eA01/1-145     AC Q8PUB7
#=GS 2q2eA01/1-145     OS Methanosarcina mazei Go1
#=GS 2q2eA01/1-145     DE Type 2 DNA topoisomerase 6 subunit A
#=GS 2q2eA01/1-145     DR CATH; 2q2e; A:15-145; 
#=GS 2q2eA01/1-145     DR ORG; Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina; Methanosarcina mazei; 
#=GS Q8TQF8/5-149      AC Q8TQF8
#=GS Q8TQF8/5-149      OS Methanosarcina acetivorans C2A
#=GS Q8TQF8/5-149      DE Type 2 DNA topoisomerase 6 subunit A
#=GS Q8TQF8/5-149      DR ORG; Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina; Methanosarcina acetivorans; 
#=GS Q8TQF8/5-149      DR EC; 5.6.2.3; 
#=GS B0R4D2/1-142      AC B0R4D2
#=GS B0R4D2/1-142      OS Halobacterium salinarum R1
#=GS B0R4D2/1-142      DE Type 2 DNA topoisomerase 6 subunit A
#=GS B0R4D2/1-142      DR ORG; Archaea; Euryarchaeota; Halobacteria; Halobacteriales; Halobacteriaceae; Halobacterium; Halobacterium salinarum; 
#=GS B0R4D2/1-142      DR EC; 5.6.2.3; 
#=GS Q57815/5-142      AC Q57815
#=GS Q57815/5-142      OS Methanocaldococcus jannaschii DSM 2661
#=GS Q57815/5-142      DE Type 2 DNA topoisomerase 6 subunit A
#=GS Q57815/5-142      DR ORG; Archaea; Euryarchaeota; Methanococci; Methanococcales; Methanocaldococcaceae; Methanocaldococcus; Methanocaldococcus jannaschii; 
#=GS Q57815/5-142      DR EC; 5.6.2.3; 
#=GS Q5JH82/11-154     AC Q5JH82
#=GS Q5JH82/11-154     OS Thermococcus kodakarensis KOD1
#=GS Q5JH82/11-154     DE Type 2 DNA topoisomerase 6 subunit A
#=GS Q5JH82/11-154     DR ORG; Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; Thermococcus; Thermococcus kodakarensis; 
#=GS Q5JH82/11-154     DR EC; 5.6.2.3; 
#=GS A9A3P1/7-149      AC A9A3P1
#=GS A9A3P1/7-149      OS Nitrosopumilus maritimus SCM1
#=GS A9A3P1/7-149      DE Type 2 DNA topoisomerase 6 subunit A
#=GS A9A3P1/7-149      DR ORG; Archaea; Thaumarchaeota; Nitrosopumilales; Nitrosopumilaceae; Nitrosopumilus; Nitrosopumilus maritimus; 
#=GS Q97ZE9/1-158      AC Q97ZE9
#=GS Q97ZE9/1-158      OS Saccharolobus solfataricus P2
#=GS Q97ZE9/1-158      DE Type 2 DNA topoisomerase 6 subunit A
#=GS Q97ZE9/1-158      DR ORG; Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae; Saccharolobus; Saccharolobus solfataricus; 
#=GS Q8ZVL9/1-145      AC Q8ZVL9
#=GS Q8ZVL9/1-145      OS Pyrobaculum aerophilum str. IM2
#=GS Q8ZVL9/1-145      DE Type 2 DNA topoisomerase 6 subunit A
#=GS Q8ZVL9/1-145      DR ORG; Archaea; Crenarchaeota; Thermoprotei; Thermoproteales; Thermoproteaceae; Pyrobaculum; Pyrobaculum aerophilum; 
#=GS 2zbkE01/1-158     AC O05208
#=GS 2zbkE01/1-158     OS Saccharolobus shibatae
#=GS 2zbkE01/1-158     DE Type 2 DNA topoisomerase 6 subunit A
#=GS 2zbkE01/1-158     DR CATH; 2zbk; E:10-158; 
#=GS 2zbkE01/1-158     DR ORG; Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae; Saccharolobus; Saccharolobus shibatae; 
#=GS 2zbkE01/1-158     DR GO; GO:0005515; 
#=GS 2zbkE01/1-158     DR EC; 5.6.2.3; 
#=GS 2zbkC01/1-158     AC O05208
#=GS 2zbkC01/1-158     OS Saccharolobus shibatae
#=GS 2zbkC01/1-158     DE Type 2 DNA topoisomerase 6 subunit A
#=GS 2zbkC01/1-158     DR CATH; 2zbk; C:10-158; 
#=GS 2zbkC01/1-158     DR ORG; Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae; Saccharolobus; Saccharolobus shibatae; 
#=GS 2zbkC01/1-158     DR GO; GO:0005515; 
#=GS 2zbkC01/1-158     DR EC; 5.6.2.3; 
#=GS 2zbkA01/1-158     AC O05208
#=GS 2zbkA01/1-158     OS Saccharolobus shibatae
#=GS 2zbkA01/1-158     DE Type 2 DNA topoisomerase 6 subunit A
#=GS 2zbkA01/1-158     DR CATH; 2zbk; A:10-158; 
#=GS 2zbkA01/1-158     DR ORG; Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae; Saccharolobus; Saccharolobus shibatae; 
#=GS 2zbkA01/1-158     DR GO; GO:0005515; 
#=GS 2zbkA01/1-158     DR EC; 5.6.2.3; 
#=GS A0A087S1N4/8-149  AC A0A087S1N4
#=GS A0A087S1N4/8-149  OS Marine Group I thaumarchaeote SCGC AAA799-P11
#=GS A0A087S1N4/8-149  DE Type 2 DNA topoisomerase 6 subunit A
#=GS A0A087S1N4/8-149  DR ORG; Archaea; Thaumarchaeota; Marine Group I thaumarchaeote SCGC AAA799-P11; 
#=GS A0A0E3SLX6/2-145  AC A0A0E3SLX6
#=GS A0A0E3SLX6/2-145  OS Methanosarcina barkeri 3
#=GS A0A0E3SLX6/2-145  DE Type 2 DNA topoisomerase 6 subunit A
#=GS A0A0E3SLX6/2-145  DR ORG; Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina; Methanosarcina barkeri; 
#=GS A0A0E3KVM4/2-145  AC A0A0E3KVM4
#=GS A0A0E3KVM4/2-145  OS Methanosarcina sp. WWM596
#=GS A0A0E3KVM4/2-145  DE Type 2 DNA topoisomerase 6 subunit A
#=GS A0A0E3KVM4/2-145  DR ORG; Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina; Methanosarcina sp. WWM596; 
#=GS A0A0E3L4Z7/2-145  AC A0A0E3L4Z7
#=GS A0A0E3L4Z7/2-145  OS Methanosarcina sp. WH1
#=GS A0A0E3L4Z7/2-145  DE Type 2 DNA topoisomerase 6 subunit A
#=GS A0A0E3L4Z7/2-145  DR ORG; Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina; Methanosarcina sp. WH1; 
#=GS D5VU15/5-142      AC D5VU15
#=GS D5VU15/5-142      OS Methanocaldococcus infernus ME
#=GS D5VU15/5-142      DE Type 2 DNA topoisomerase 6 subunit A
#=GS D5VU15/5-142      DR ORG; Archaea; Euryarchaeota; Methanococci; Methanococcales; Methanocaldococcaceae; Methanocaldococcus; Methanocaldococcus infernus; 
#=GS C5A6R6/11-155     AC C5A6R6
#=GS C5A6R6/11-155     OS Thermococcus gammatolerans EJ3
#=GS C5A6R6/11-155     DE Type 2 DNA topoisomerase 6 subunit A
#=GS C5A6R6/11-155     DR ORG; Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; Thermococcus; Thermococcus gammatolerans; 
#=GS O05208/1-158      AC O05208
#=GS O05208/1-158      OS Saccharolobus shibatae
#=GS O05208/1-158      DE Type 2 DNA topoisomerase 6 subunit A
#=GS O05208/1-158      DR ORG; Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae; Saccharolobus; Saccharolobus shibatae; 
#=GS O05208/1-158      DR GO; GO:0005515; 
#=GS O05208/1-158      DR EC; 5.6.2.3; 
#=GS Q9HR32/1-142      AC Q9HR32
#=GS Q9HR32/1-142      OS Halobacterium salinarum NRC-1
#=GS Q9HR32/1-142      DE Type 2 DNA topoisomerase 6 subunit A
#=GS Q9HR32/1-142      DR ORG; Archaea; Euryarchaeota; Halobacteria; Halobacteriales; Halobacteriaceae; Halobacterium; Halobacterium salinarum; 
#=GS Q9HR32/1-142      DR EC; 5.6.2.3; 
#=GS D0KTU0/1-158      AC D0KTU0
#=GS D0KTU0/1-158      OS Saccharolobus solfataricus 98/2
#=GS D0KTU0/1-158      DE Type 2 DNA topoisomerase 6 subunit A
#=GS D0KTU0/1-158      DR ORG; Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae; Saccharolobus; Saccharolobus solfataricus; 
#=GS A0A0E3GTP8/1-158  AC A0A0E3GTP8
#=GS A0A0E3GTP8/1-158  OS Saccharolobus solfataricus
#=GS A0A0E3GTP8/1-158  DE Type 2 DNA topoisomerase 6 subunit A
#=GS A0A0E3GTP8/1-158  DR ORG; Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae; Saccharolobus; Saccharolobus solfataricus; 
#=GF SQ 22
2zbkG01/1-158             MSSEFISKVDKEARRK-AANILRDKFLNLVEQLKKGEPLVMEIPMRTLSNAIYDEKRKLLLLGEKKLRRNFLDLNEAKRFMQTVLMASI-IYDALVSDEYPTIRDLYYRGKHSLLLKSIEGNKIVSEENTWDEQKESDSVIVDIEVFTSLLREEMLILSK
2q2eA01/1-145             M-EGEKGSKTRKGDAL-AREKLLEIAEKIYNQFEEEVVPSVSLPSRTKANLEYSDESDVWVYGDRESERSAKTVKGAFQLLKTTYATDFLINEHLARNRGSTLRELYYISEGW-------------DYAKFKEQGESDRLIEDLEILTSLQREYFHMRPE
Q8TQF8/5-149              V-NNEVNSKKRQGDTL-AKERLLGLAEKIYNQFEEEVIPSVSLPSRTKANIEYSDESDVWVYGDRESERSAKTVKGAFQLLKTTYATDFLINEHLAHNRGSTLRELYYISEGW-------------DYAKFKEQAESDRLIEDLELLTSLQREYFHMRPE
B0R4D2/1-142              ------MSETHTSDETEARDQLLAIAEQFYDQFADGDIPRMSLPTRSKSNIEYDEDADVWVYGDSQSTRSANSVRGARKLLKSVYTVDF-LAQQLDEGRSSTLRELYYLSESW-----------DEAEAQFNDQSESDKLVEDLEIVSGVKREDFHMRPE
Q57815/5-142              ------PAISKKPREI-AKQKIIELAKKMYEDLMKGKRPKITMPIRSLSNAMFDKEKGSFTLVGKEKART-LTVNQAKIFAQTTKMLEF-AKQLLETDDFSTLREAYYVSKNW-------------GEARFDDQQASNNVIEDLEAALGVLREHLGFIPE
Q5JH82/11-154             ------PKEKFSYDPRKVLKMLDEHARRILEDIKAGKNPHFDIPMRGLSNVYFDEKSRLIKMGDKLSRRYFLNVAHARKFMQTLLIMAY-VKRLVSEGKHASLREAYYANKHTIP---------GTRENTFEDQSESDPIIEDLERMFGVLREEMHITAD
A9A3P1/7-149              K-AKEISKKAKEKQKT-ILESLKNHGAKIYEDLENGQFPKFSIPSRSVSNIVYDKKLRQYILGNSTALRSAKNSAQLRSFTQLMWLAFF-ANRLTQEKKSSTLRDVYYSSQAF--------------AIEFDDQSESDNIIVDLEAVTSRPREDFHIFPE
Q97ZE9/1-158              MSSEFISKVDKEARRK-AASILRDKFLNLVEQLKKGEPLVMEIPMRTLSNAIYDEKRKLLLLGEKKLKRNFLDMNEAKRFMQTVLMASI-IYDALVSDEYPTIRDLYYRGKHSLLLKSIDGNKIVSEENTWDEQKESDSVIVDIEVFTSLLREEMLILSK
Q8ZVL9/1-145              M-----------STRSEFLKRLESWGTQLAKAILELEEPIMEIPARTLSNTIWDEKARMLKLGPEKLHRRFLDVKEARKFMQTVLMLRL-IVEAIREDVYPTIRDLYYNGKHTIVFKDPLGR--THRENTWDEQSESNAVIEDIEVATNVLREEMGVSA-
2zbkE01/1-158             MSSEFISKVDKEARRK-AANILRDKFLNLVEQLKKGEPLVMEIPMRTLSNAIYDEKRKLLLLGEKKLRRNFLDLNEAKRFMQTVLMASI-IYDALVSDEYPTIRDLYYRGKHSLLLKSIEGNKIVSEENTWDEQKESDSVIVDIEVFTSLLREEMLILSK
2zbkC01/1-158             MSSEFISKVDKEARRK-AANILRDKFLNLVEQLKKGEPLVMEIPMRTLSNAIYDEKRKLLLLGEKKLRRNFLDLNEAKRFMQTVLMASI-IYDALVSDEYPTIRDLYYRGKHSLLLKSIEGNKIVSEENTWDEQKESDSVIVDIEVFTSLLREEMLILSK
2zbkA01/1-158             MSSEFISKVDKEARRK-AANILRDKFLNLVEQLKKGEPLVMEIPMRTLSNAIYDEKRKLLLLGEKKLRRNFLDLNEAKRFMQTVLMASI-IYDALVSDEYPTIRDLYYRGKHSLLLKSIEGNKIVSEENTWDEQKESDSVIVDIEVFTSLLREEMLILSK
A0A087S1N4/8-149          --AKAISKKAKEKQKS-ILEALKKHGAKIYEDLENGQFPKFSIPSRSVSNIVYDKKLRQYILGNSTALRSAKNSAQLRSFTQLMWLAFF-ANRLTQEKKSSTLRDVYYSSQAF--------------AIEFDDQSESDNIIVDLEAVTSRPREDFHIFPE
A0A0E3SLX6/2-145          --ARETNSKTIQGDAL-AKEKLLELAEKIYNQFENEVVPSVSLPSRTKANIEYSDESDVWVYGDRESERSAKTVKGAFQLLKTTYATDFLINEHLAHNRGSTLRELYYISEGW-------------EAAKFKEQAESDRLIEDLELLTALQREYFHMRPE
A0A0E3KVM4/2-145          --ARESNSKTRQGDAL-AKERLLGLAEKIYNQFEDEIVPSVSLPSRTKANIEYSDESDVWVYGTRESERSAKTVKGAFQLLKTTYATDFLINEHLAQNRGSTLRELYYISEGW-------------DAAKFKEQAESDRLIEDLELLTSLQREYFHMRPE
A0A0E3L4Z7/2-145          --ARESNSKTRQGDAL-AKERLLGLAEKIYNQFEDEIVPSVSLPSRTKANIEYSDESDVWVYGTRESERSAKTVKGAFQLLKTTYATDFLINEHLAQNRGSTLRELYYISEGW-------------DAAKFKEQAESDRLIEDLELLTSLQREYFHMRPE
D5VU15/5-142              ------PKIPKKPREI-AKQKIIELAKKMYDDLMKGKRPKIKMPIRSLSNALFDRKKGSFTLVGKEKERT-LTVSQAKIFAQTTKMMEF-AKELLENDDFSTLREAYYVSKNW-------------GEARFDDQQASNNVIEDLEAALGVLREHLGFVPE
C5A6R6/11-155             K-----PKEKFSYDPKKVLSKLEEYGRSVLEAIKSGKNPYFDIPMRGLNNVYFDEKSRLIKMGDKLSRRYFLNVAHARKFMQTLLIMAY-VKRLVSEGKHASLREAYYANKHTIP---------GTRENTFEDQRESDPIIEDLERMLGVLREEMHITAD
O05208/1-158              MSSEFISKVDKEARRK-AANILRDKFLNLVEQLKKGEPLVMEIPMRTLSNAIYDEKRKLLLLGEKKLRRNFLDLNEAKRFMQTVLMASI-IYDALVSDEYPTIRDLYYRGKHSLLLKSIEGNKIVSEENTWDEQKESDSVIVDIEVFTSLLREEMLILSK
Q9HR32/1-142              ------MSETHTSDETEARDQLLAIAEQFYDQFADGDIPRMSLPTRSKSNIEYDEDADVWVYGDSQSTRSANSVRGARKLLKSVYTVDF-LAQQLDEGRSSTLRELYYLSESW-----------DEAEAQFNDQSESDKLVEDLEIVSGVKREDFHMRPE
D0KTU0/1-158              MSSEFISKVDKEARRK-AASILRDKFLNLVEQLKKGEPLVMEIPMRTLSNAIYDEKRKLLLLGEKKLKRNFLDMNEAKRFMQTVLMASI-IYDALVSDEYPTIRDLYYRGKHSLLLKSIDGNKIVSEENTWDEQKESDSVIVDIEVFTSLLREEMLILSK
A0A0E3GTP8/1-158          MSSEFISKVDKEARRK-AASILRDKFLNLVEQLKKGEPLVMEIPMRTLSNAIYDEKRKLLLLGEKKLKRNFLDMNEAKRFMQTVLMASI-IYDALVSDEYPTIRDLYYRGKHSLLLKSIDGNKIVSEENTWDEQKESDSVIVDIEVFTSLLREEMLILSK
#=GC scorecons            1021124433443443063438343435545554463363546949546953766634444574544394344544744656654443505353634543576976993554311010001000113554557947974685969445554994545355
#=GC scorecons_70         _________________*___*________________*___**_*__**__**________*_____*_______*__*_**___________*______****_**________________________**_***__*_***______**_______
#=GC scorecons_80         _____________________*_____________________*_*___*__*_________*_____*_______*________________________*_*__**_________________________*_***__*_*_*______**_______
#=GC scorecons_90         ___________________________________________*_*___*__________________*__________________________________*__**_________________________*__*___*_*_*______**_______
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