CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1460 |
Domain Context
CATH Clusters
| Superfamily | 3.40.50.1460 |
| Functional Family | Legumain |
Enzyme Information
| 3.4.22.34 |
Legumain.
based on mapping to UniProt Q99538
Hydrolysis of proteins and small molecule substrates at -Asn-|- Xaa- bonds.
-!- Best known from legume seeds, the trematode Schistosoma mansoni and mammalian lysosomes. -!- Not inhibited by compound E-64. -!- Belongs to peptidase family C13.
|
UniProtKB Entries (1)
| Q99538 |
LGMN_HUMAN
Homo sapiens
Legumain
|
PDB Structure
| PDB | 5LU8 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
Nat Commun
|
