CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.520 | Peroxidase; domain 1 |
|
1.10.520.10 |
Domain Context
CATH Clusters
| Superfamily | 1.10.520.10 |
| Functional Family | Catalase-peroxidase |
Enzyme Information
| 1.11.1.21 |
Catalase peroxidase.
based on mapping to UniProt A4QUT2
(1) Donor + H(2)O(2) = oxidized donor + 2 H(2)O. (2) 2 H(2)O(2) = O(2) + 2 H(2)O.
-!- Differs from EC 1.11.1.7, peroxidase, in having a relatively high catalase (EC 1.11.1.6) activity with H(2)O(2) as donor, releasing O(2); both activities use the same heme active site. -!- In Mycobacterium tuberculosis it is responsible for activation of the commonly used antitubercular drug, isoniazid.
|
UniProtKB Entries (1)
| A4QUT2 |
KATG2_MAGO7
Pyricularia oryzae 70-15
Catalase-peroxidase 2
|
PDB Structure
| PDB | 5CJH |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Eukaryotic Catalase-Peroxidase: The Role of the Trp-Tyr-Met Adduct in Protein Stability, Substrate Accessibility, and Catalysis of Hydrogen Peroxide Dismutation.
Biochemistry
|
