CATH Domain 4zw7A04

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.40	Immunoglobulin-like
	2.60.40.1840	Aminopeptidase N, middle-beta domain

Domain Context

CATH Clusters

Superfamily	2.60.40.1840
Functional Family	Aminopeptidase N

Enzyme Information

3.4.11.-

Aminopeptidases.

based on mapping to UniProt O96935

UniProtKB Entries (1)

AMP1_PLAFQ

Plasmodium falciparum FcB1/Columbia

M1 family aminopeptidase

PDB Structure

PDB	4ZW7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Drinkwater, N., Vinh, N.B., Mistry, S.N., Bamert, R.S., Ruggeri, C., Holleran, J.P., Loganathan, S., Paiardini, A., Charman, S.A., Powell, A.K., Avery, V.M., McGowan, S., Scammells, P.J. Eur.J.Med.Chem.