CATH Domain 4xryA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.630	Cytochrome p450
	1.10.630.10	Cytochrome P450

Domain Context

CATH Clusters

Superfamily	Cytochrome P450
Functional Family	cytochrome P450 2D15 isoform X1

Enzyme Information

1.14.14.1

Unspecific monooxygenase.

based on mapping to UniProt P10635

RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.

-!- Acts on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalyzed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groups. -!- Together with EC 1.6.2.4, it forms a system in which two reducing equivalents are supplied by NADPH. -!- Some of the reactions attributed to EC 1.14.15.3 belong here. -!- Formerly EC 1.14.1.1, EC 1.14.14.2, EC 1.14.99.8 and EC 1.99.1.1.

UniProtKB Entries (1)

P10635

CP2D6_HUMAN

Homo sapiens

Cytochrome P450 2D6

PDB Structure

PDB	4XRY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug-Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors. Brodney, M.A., Beck, E.M., Butler, C.R., Barreiro, G., Johnson, E.F., Riddell, D., Parris, K., Nolan, C.E., Fan, Y., Atchison, K., Gonzales, C., Robshaw, A.E., Doran, S.D., Bundesmann, M.W., Buzon, L., Dutra, J., Henegar, K., LaChapelle, E., Hou, X., Rogers, B.N., Pandit, J., Lira, R., Martinez-Alsina, L., Mikochik, P., Murray, J.C., Ogilvie, K., Price, L., Sakya, S.M., Yu, A., Zhang, Y., O'Neill, B.T. J.Med.Chem.