CATH Domain 4usfA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	STE20-like serine/threonine-protein kinase

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt Q9H2G2

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q9H2G2

SLK_HUMAN

Homo sapiens

STE20-like serine/threonine-protein kinase

PDB Structure

PDB	4USF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Comprehensive Characterization of the Published Kinase Inhibitor Set. Elkins, J.M., Fedele, V., Szklarz, M., Abdul Azeez, K.R., Salah, E., Mikolajczyk, J., Romanov, S., Sepetov, N., Huang, X.P., Roth, B.L., Al Haj Zen, A., Fourches, D., Muratov, E., Tropsha, A., Morris, J., Teicher, B.A., Kunkel, M., Polley, E., Lackey, K.E., Atkinson, F.L., Overington, J.P., Bamborough, P., Moller, S., Price, D.J., Willson, T.M., Drewry, D.H., Knapp, S., Zuercher, W.J. Nat.Biotechnol.