CATH Domain 4ow3A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.170	Elastase; domain 1
	3.10.170.10

Domain Context

CATH Clusters

Superfamily	3.10.170.10
Functional Family

Enzyme Information

3.4.24.27

Thermolysin.

based on mapping to UniProt P00800

Preferential cleavage: Xaa-|-Leu > Xaa-|-Phe.

-!- A thermostable extracellular metalloendopeptidase containing four calcium ions. -!- Enzymes that may be species variants of thermolysin are reported from Micrococcus caseolyticus and Aspergillus oryzae. -!- Closely related but distinct enzymes are aeromonolysin, pseudolysin, bacillolysin, aureolysin and mycolysin. -!- Belongs to peptidase family M4. -!- Formerly EC 3.4.24.4.

UniProtKB Entries (1)

P00800

THER_BACTH

Bacillus thermoproteolyticus

Thermolysin

PDB Structure

PDB	4OW3
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Accurate macromolecular structures using minimal measurements from X-ray free-electron lasers. Hattne, J., Echols, N., Tran, R., Kern, J., Gildea, R.J., Brewster, A.S., Alonso-Mori, R., Glockner, C., Hellmich, J., Laksmono, H., Sierra, R.G., Lassalle-Kaiser, B., Lampe, A., Han, G., Gul, S., DiFiore, D., Milathianaki, D., Fry, A.R., Miahnahri, A., White, W.E., Schafer, D.W., Seibert, M.M., Koglin, J.E., Sokaras, D., Weng, T.C., Sellberg, J., Latimer, M.J., Glatzel, P., Zwart, P.H., Grosse-Kunstleve, R.W., Bogan, M.J., Messerschmidt, M., Williams, G.J., Boutet, S., Messinger, J., Zouni, A., Yano, J., Bergmann, U., Yachandra, V.K., Adams, P.D., Sauter, N.K. Nat.Methods