CATH Domain 4ny3B02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.120	Four Helix Bundle (Hemerythrin (Met), subunit A)
	1.20.120.1150	Phosphotyrosyl phosphate activator, C-terminal lid domain

Domain Context

CATH Clusters

Superfamily	1.20.120.1150
Functional Family	Serine/threonine-protein phosphatase 2A activator

Enzyme Information

5.2.1.8

Peptidylprolyl isomerase.

based on mapping to UniProt Q15257

Peptidylproline (omega=180) = peptidylproline (omega=0).

-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q15257

PTPA_HUMAN

Homo sapiens

Serine/threonine-protein phosphatase 2A activator

PDB Structure

PDB	4NY3
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A. Low, C., Quistgaard, E.M., Kovermann, M., Anandapadamanaban, M., Balbach, J., Nordlund, P. Biol.Chem.