CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.12760 |
Domain Context
CATH Clusters
| Superfamily | 3.40.50.12760 |
| Functional Family | Cap methyltransferase 1 |
Enzyme Information
| 2.1.1.57 |
Methyltransferase cap1.
based on mapping to UniProt Q8N1G2
S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)- (purine-ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)- methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)- [mRNA].
-!- This enzyme catalyzes the methylation of the ribose on the first transcribed nucleotide of mRNA or snRNA molecules, which may be either guanosine or adenosine. -!- This methylation event is known as cap1, and occurs in all mRNAs and snRNAs of higher eukaryotes, including insects, vertebrates and their viruses. -!- The human enzyme can also methylate mRNA molecules that lack methylation on the capping 5'-triphosphoguanosine. -!- Formerly EC 2.1.1.58.
|
UniProtKB Entries (1)
| Q8N1G2 |
CMTR1_HUMAN
Homo sapiens
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
|
PDB Structure
| PDB | 4N4A |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural analysis of human 2'-O-ribose methyltransferases involved in mRNA cap structure formation.
Nat Commun
|
