CATH Domain 4l0lA03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.710	Beta-lactamase
	3.40.710.10	DD-peptidase/beta-lactamase superfamily

Domain Context

CATH Clusters

Superfamily	DD-peptidase/beta-lactamase superfamily
Functional Family	Peptidoglycan D,D-transpeptidase FtsI

Enzyme Information

3.4.16.4

Serine-type D-Ala-D-Ala carboxypeptidase.

based on mapping to UniProt Q51504

Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.

-!- A group of bacterial enzymes, membrane-bound. -!- Inhibited by beta-lactam antibiotics, which acylate the active site serine in the enzyme. -!- Distinct from EC 3.4.17.14. -!- Belongs to peptidase families S11, S12 and S13.

UniProtKB Entries (1)

Q51504

Q51504_PSEAI

Pseudomonas aeruginosa

Peptidoglycan D,D-transpeptidase FtsI

PDB Structure

PDB	4L0L
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Pyridone-conjugated monobactam antibiotics with gram-negative activity. Brown, M.F., Mitton-Fry, M.J., Arcari, J.T., Barham, R., Casavant, J., Gerstenberger, B.S., Han, S., Hardink, J.R., Harris, T.M., Hoang, T., Huband, M.D., Lall, M.S., Lemmon, M.M., Li, C., Lin, J., McCurdy, S.P., McElroy, E., McPherson, C., Marr, E.S., Mueller, J.P., Mullins, L., Nikitenko, A.A., Noe, M.C., Penzien, J., Plummer, M.S., Schuff, B.P., Shanmugasundaram, V., Starr, J.T., Sun, J., Tomaras, A., Young, J.A., Zaniewski, R.P. J.Med.Chem.