CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.190 | D-Maltodextrin-Binding Protein; domain 2 |
|
3.40.190.10 | Periplasmic binding protein-like II |
Domain Context
CATH Clusters
| Superfamily | Periplasmic binding protein-like II |
| Functional Family | Maltodextrin-binding protein |
Enzyme Information
| 2.3.2.26 |
HECT-type E3 ubiquitin transferase.
based on mapping to UniProt Q05086
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)- ubiquitinyl-[acceptor protein]-L-lysine.
-!- In the first step the enzyme transfers ubiquitin from the E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) to a cysteine residue in its HECT domain (which is located in the C-terminal region), forming a thioester bond. -!- In a subsequent step the enzyme transfers the ubiquitin to an acceptor protein, resulting in the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and the epsilon- amino group of an L-lysine residue of the acceptor protein. -!- Cf. EC 2.3.2.27 and EC 2.3.2.31.
|
UniProtKB Entries (3)
| P0AEX9 |
MALE_ECOLI
Escherichia coli K-12
Maltose/maltodextrin-binding periplasmic protein
|
| Q05086 |
UBE3A_HUMAN
Homo sapiens
Ubiquitin-protein ligase E3A
|
| P03126 |
VE6_HPV16
Human papillomavirus type 16
Protein E6
|
PDB Structure
| PDB | 4GIZ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteins.
Science
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