CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.470 | Uracil-DNA Glycosylase, subunit E |
|
3.40.470.10 | Uracil-DNA glycosylase-like domain |
Domain Context
CATH Clusters
| Superfamily | Uracil-DNA glycosylase-like domain |
| Functional Family | G/T mismatch-specific thymine DNA glycosylase |
Enzyme Information
| 3.2.2.29 |
Thymine-DNA glycosylase.
based on mapping to UniProt Q13569
Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine.
-!- Thymine-DNA glycosylase is part of the DNA-repair machinery. -!- Thymine removal is fastest when it is from a G/T mismatch with a 5'-flanking C/G pair. -!- The glycosylase removes uracil from G/U, C/U, and T/U base pairs faster than it removes thymine from G/T.
|
UniProtKB Entries (1)
| Q13569 |
TDG_HUMAN
Homo sapiens
G/T mismatch-specific thymine DNA glycosylase
|
PDB Structure
| PDB | 4FNC |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation.
Nucleic Acids Res.
|
