CATH Domain 4cyeA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.80	Acyl-CoA Binding Protein
	1.20.80.10

Domain Context

CATH Clusters

Superfamily	1.20.80.10
Functional Family	Protein-tyrosine kinase 2-beta isoform 1

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt Q00944

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q00944

FAK1_CHICK

Gallus gallus

Focal adhesion kinase 1

PDB Structure

PDB	4CYE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Phosphatidylinositol 4,5-Bisphosphate Triggers Activation of Focal Adhesion Kinase by Inducing Clustering and Conformational Changes. Goni, G.M., Epifano, C., Boskovic, J., Camacho-Artacho, M., Zhou, J., Bronowska, A., Martin, M.T., Eck, M.J., Kremer, L., Grater, F., Gervasio, F.L., Perez-Moreno, M., Lietha, D. Proc.Natl.Acad.Sci.USA