CATH Domain 4codB00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Enoyl-[acyl-carrier-protein] reductase [NADH]

Enzyme Information

1.3.1.9

Enoyl-[acyl-carrier-protein] reductase (NADH).

based on mapping to UniProt P9WGR1

An acyl-[acyl-carrier protein] + NAD(+) = a trans-2,3-dehydroacyl-[acyl- carrier protein] + NADH.

-!- The enzyme catalyzes an essential step in fatty acid biosynthesis, the reduction of the 2,3-double bond in enoyl-acyl-[acyl-carrier- protein] derivatives of the elongating fatty acid moiety. -!- The enzyme from the bacterium Escherichia coli accepts substrates with carbon chain length from 4 to 18. -!- The FAS-I enzyme from the bacterium Mycobacterium tuberculosis prefers substrates with carbon chain length from 12 to 24 carbons.

UniProtKB Entries (1)

P9WGR1

INHA_MYCTU

Mycobacterium tuberculosis H37Rv

Enoyl-[acyl-carrier-protein] reductase [NADH]

PDB Structure

PDB	4COD
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Encoded Library Technology as a Source of Hits for the Discovery and Lead Optimization of a Potent and Selective Class of Bactericidal Direct Inhibitors of Mycobacterium Tuberculosis Inha. Encinas, L., O'Keefe, H., Neu, M., Remuinan, M.J., Patel, A.M., Guardia, A., Davie, C.P., Perez-Macias, N., Yang, H., Convery, M.A., Messer, J.A., Perez-Herran, E., Centrella, P.A., Alvarez-Gomez, D., Clark, M.A., Huss, S., O'Donovan, G.K., Ortega-Muro, F., Mcdowell, W., Castaneda, P., Arico-Muendel, C.C., Pajk, S., Rullas, J., Angulo-Barturen, I., Alvarez-Ruiz, E., Mendoza-Losana, A., Pages, L.B., Castro-Pichel, J., Evindar, G. J.Med.Chem.