CATH Domain 4ckrA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Epithelial discoidin domain-containing receptor 1

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt Q08345

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q08345

DDR1_HUMAN

Homo sapiens

Epithelial discoidin domain-containing receptor 1

PDB Structure

PDB	4CKR
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of a Potent and Selective Ddr1 Receptor Tyrosine Kinase Inhibitor. Kim, H., Tan, L., Weisberg, E.L., Liu, F., Canning, P., Choi, H.G., Ezell, S.A., Wu, H., Zhao, Z., Wang, J., Mandinova, A., Griffin, J.D., Bullock, A.N., Liu, Q., Lee, S.W., Gray, N.S. Acs Chem.Biol.