CATH Domain 4a2sA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.70	Aldolase class I

Domain Context

CATH Clusters

Superfamily	Aldolase class I
Functional Family

Enzyme Information

4.1.1.48

Indole-3-glycerol-phosphate synthase.

based on mapping to UniProt Q06121

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C- (3-indolyl)-glycerol 3-phosphate + CO(2) + H(2)O.

-!- In some organisms, this enzyme is part of a multifunctional protein together with one or more components of the system for biosynthesis of tryptophan (EC 2.4.2.18, EC 4.1.3.27, EC 4.2.1.20 and EC 5.3.1.24).

UniProtKB Entries (1)

Q06121

TRPC_SACS2

Saccharolobus solfataricus P2

Indole-3-glycerol phosphate synthase

PDB Structure

PDB	4A2S
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Evolution of a designed retro-aldolase leads to complete active site remodeling. Giger, L., Caner, S., Obexer, R., Kast, P., Baker, D., Ban, N., Hilvert, D. Nat.Chem.Biol.