CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.150 | DNA polymerase; domain 1 |
|
1.10.150.110 | DNA polymerase beta, N-terminal domain-like |
Domain Context
CATH Clusters
| Superfamily | DNA polymerase beta, N-terminal domain-like |
| Functional Family | DNA polymerase beta |
Enzyme Information
| 4.2.99.- |
Other carbon-oxygen lyases.
based on mapping to UniProt P06766
|
| 2.7.7.7 |
DNA-directed DNA polymerase.
based on mapping to UniProt P06766
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
|
UniProtKB Entries (1)
| P06766 |
DPOLB_RAT
Rattus norvegicus
DNA polymerase beta
|
PDB Structure
| PDB | 3V7L |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystallographic studies of K72E mutant DNA polymerase explain loss of lyase function and reveal changes in the overall conformational state of the polymerase domain
To be Published
|
