CATH Classification

Domain Context

CATH Clusters

Superfamily Rubisco LSMT, substrate-binding domain
Functional Family histone-lysine N-methyltransferase setd3 isoform X1

Enzyme Information

2.1.1.85
Protein-histidine N-methyltransferase.
based on mapping to UniProt Q86TU7
S-adenosyl-L-methionine + protein L-histidine = S-adenosyl-L-homocysteine + protein N(tau)-methyl-L-histidine.
-!- Highly specific for histidine residues, for example, in actin.

UniProtKB Entries (1)

Q86TU7
SETD3_HUMAN
Homo sapiens
Actin-histidine N-methyltransferase

PDB Structure

PDB 3SMT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of human SET domain-containing protein3
Zeng, H., Dong, A., Walker, J.R., Loppnau, P., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Min, J., Wu, H.
To be Published
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