CATH Domain 3smrA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.130	7 Propeller
	2.130.10	Methylamine Dehydrogenase; Chain H
	2.130.10.10	YVTN repeat-like/Quinoprotein amine dehydrogenase

Domain Context

CATH Clusters

Superfamily	YVTN repeat-like/Quinoprotein amine dehydrogenase
Functional Family	WD repeat-containing protein 5

Enzyme Information

UniProtKB Entries (1)

WDR5_HUMAN

Homo sapiens

WD repeat-containing protein 5

PDB Structure

PDB	3SMR
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. Senisterra, G., Wu, H., Allali-Hassani, A., Wasney, G.A., Barsyte-Lovejoy, D., Dombrovski, L., Dong, A., Nguyen, K.T., Smil, D., Bolshan, Y., Hajian, T., He, H., Seitova, A., Chau, I., Li, F., Poda, G., Couture, J.F., Brown, P.J., Al-Awar, R., Schapira, M., Arrowsmith, C.H., Vedadi, M. Biochem. J.