CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Serine protease 37

Enzyme Information

3.4.21.39
Chymase.
based on mapping to UniProt P23946
Preferential cleavage: Phe-|-Xaa > Tyr-|-Xaa > Trp-|-Xaa > Leu-|-Xaa.
-!- In mast cell granules. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P23946
CMA1_HUMAN
Homo sapiens
Chymase

PDB Structure

PDB 3S0N
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Benzimidazolone as potent chymase inhibitor: Modulation of reactive metabolite formation in the hydrophobic (P(1)) region.
Lo, H.Y., Nemoto, P.A., Kim, J.M., Hao, M.H., Qian, K.C., Farrow, N.A., Albaugh, D.R., Fowler, D.M., Schneiderman, R.D., Michael August, E., Martin, L., Hill-Drzewi, M., Pullen, S.S., Takahashi, H., De Lombaert, S.
Bioorg.Med.Chem.Lett.
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