CATH Domain 3oz2A02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.9	D-Amino Acid Oxidase; Chain A, domain 2
	3.30.9.10	D-Amino Acid Oxidase, subunit A, domain 2

Domain Context

CATH Clusters

Superfamily	D-Amino Acid Oxidase, subunit A, domain 2
Functional Family

Enzyme Information

1.3.1.101

2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase (NAD(P)H).

based on mapping to UniProt Q9HKS9

2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate + 8 NAD(P)(+) = 2,3-bis- (O-geranylgeranyl)-sn-glycerol 1-phosphate + 8 NAD(P)H.

-!- The enzyme from the archaeon Thermoplasma acidophilum is involved in the biosynthesis of membrane lipids. -!- In vivo the reaction occurs in the reverse direction with the formation of 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate. -!- cf. EC 1.3.7.11.

UniProtKB Entries (1)

Q9HKS9

GGR_THEAC

Thermoplasma acidophilum DSM 1728

Digeranylgeranylglycerophospholipid reductase

PDB Structure

PDB	3OZ2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Insights into substrate specificity of geranylgeranyl reductases revealed by the structure of digeranylgeranylglycerophospholipid reductase, an essential enzyme in the biosynthesis of archaeal membrane lipids. Xu, Q., Eguchi, T., Mathews, I.I., Rife, C.L., Chiu, H.J., Farr, C.L., Feuerhelm, J., Jaroszewski, L., Klock, H.E., Knuth, M.W., Miller, M.D., Weekes, D., Elsliger, M.A., Deacon, A.M., Godzik, A., Lesley, S.A., Wilson, I.A. J.Mol.Biol.