CATH Domain 3o88A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.710	Beta-lactamase
	3.40.710.10	DD-peptidase/beta-lactamase superfamily

Domain Context

CATH Clusters

Superfamily	DD-peptidase/beta-lactamase superfamily
Functional Family	Beta-lactamase

Enzyme Information

3.5.2.6

Beta-lactamase.

based on mapping to UniProt P00811

A beta-lactam + H(2)O = a substituted beta-amino acid.

-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P00811

AMPC_ECOLI

Escherichia coli K-12

Beta-lactamase

PDB Structure

PDB	3O88
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Design, Synthesis, Crystal Structures, and Antimicrobial Activity of Sulfonamide Boronic Acids as beta-Lactamase Inhibitors Eidam, O., Romagnoli, C., Caselli, E., Babaoglu, K., Pohlhaus, D.T., Karpiak, J., Bonnet, R., Shoichet, B.K., Prati, F. J.Med.Chem.