CATH Domain 3o2mA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Mitogen-activated protein kinase

Enzyme Information

2.7.11.24

Mitogen-activated protein kinase.

based on mapping to UniProt P45983

ATP + a protein = ADP + a phosphoprotein.

-!- Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2 is necessary for enzyme activation. -!- Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline. -!- A distinguishing feature of all MAPKs is the conserved sequence Thr- Xaa-Tyr (TXY). -!- Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. -!- Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (2)

Q9WVI9	JIP1_MOUSE Mus musculus C-Jun-amino-terminal kinase-interacting protein 1
P45983	MK08_HUMAN Homo sapiens Mitogen-activated protein kinase 8

PDB Structure

PDB	3O2M
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases. Comess, K.M., Sun, C., Abad-Zapatero, C., Goedken, E.R., Gum, R.J., Borhani, D.W., Argiriadi, M., Groebe, D.R., Jia, Y., Clampit, J.E., Haasch, D.L., Smith, H.T., Wang, S., Song, D., Coen, M.L., Cloutier, T.E., Tang, H., Cheng, X., Quinn, C., Liu, B., Xin, Z., Liu, G., Fry, E.H., Stoll, V., Ng, T.I., Banach, D., Marcotte, D., Burns, D.J., Calderwood, D.J., Hajduk, P.J. Acs Chem.Biol.