CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.510 | Transferase(Phosphotransferase); domain 1 | |
1.10.510.10 | Transferase(Phosphotransferase) domain 1 |
Domain Context
CATH Clusters
Superfamily | Transferase(Phosphotransferase) domain 1 |
Functional Family | Serine/threonine-protein kinase/endoribonuclease IRE1 |
Enzyme Information
3.1.26.- |
Endoribonucleases producing 5'-phosphomonoesters.
based on mapping to UniProt P32361
|
2.7.11.1 |
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P32361
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
|
UniProtKB Entries (1)
P32361 |
IRE1_YEAST
Saccharomyces cerevisiae S288C
Serine/threonine-protein kinase/endoribonuclease IRE1
|
PDB Structure
PDB | 3LJ0 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1.
Mol.Cell
|