CATH Domain 3l29A02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.10	Ribbon
	2.10.10	Seminal Fluid Protein PDC-109 (Domain B)
	2.10.10.70	Filoviridae VP35, C-terminal inhibitory domain, beta-sheet subdomain

Domain Context

CATH Clusters

Superfamily	Filoviridae VP35, C-terminal inhibitory domain, beta-sheet subdomain
Functional Family	Polymerase cofactor VP35

Enzyme Information

UniProtKB Entries (1)

VP35_EBOZM

Ebola virus - Mayinga, Zaire, 1976

Polymerase cofactor VP35

PDB Structure

PDB	3L29
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Mutations abrogating VP35 interaction with double-stranded RNA render ebola virus avirulent in guinea pigs. Prins, K.C., Delpeut, S., Leung, D.W., Reynard, O., Volchkova, V.A., Reid, S.P., Ramanan, P., Cardenas, W.B., Amarasinghe, G.K., Volchkov, V.E., Basler, C.F. J.Virol.