CATH Domain 3iofA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.60	4-Layer Sandwich
	3.60.15	Metallo-beta-lactamase; Chain A
	3.60.15.10	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like

Domain Context

CATH Clusters

Superfamily	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Functional Family

Enzyme Information

3.5.2.6

Beta-lactamase.

based on mapping to UniProt P26918

A beta-lactam + H(2)O = a substituted beta-amino acid.

-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P26918

BLAB_AERHY

Aeromonas hydrophila

Metallo-beta-lactamase type 2

PDB Structure

PDB	3IOF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Mercaptophosphonate Compounds as Broad-Spectrum Inhibitors of the Metallo-beta-lactamases Lassaux, P., Hamel, M., Gulea, M., Delbruck, H., Mercuri, P.S., Horsfall, L., Dehareng, D., Kupper, M., Frere, J.-M., Hoffmann, K., Galleni, M., Bebrone, C. J.Med.Chem.