CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.40 | Immunoglobulin-like |
|
2.60.40.180 | Transthyretin/hydroxyisourate hydrolase domain |
Domain Context
CATH Clusters
| Superfamily | Transthyretin/hydroxyisourate hydrolase domain |
| Functional Family | Transthyretin |
Enzyme Information
UniProtKB Entries (1)
| P02766 |
TTHY_HUMAN
Homo sapiens
Transthyretin
|
PDB Structure
| PDB | 3IMV |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity.
J.Am.Chem.Soc.
|
