CATH Domain 3hibA01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.3380	Sec63 N-terminal domain-like fold
	1.10.3380.10	Sec63 N-terminal domain-like domain

Domain Context

CATH Clusters

Superfamily	Sec63 N-terminal domain-like domain
Functional Family

Enzyme Information

3.6.4.13

RNA helicase.

based on mapping to UniProt P32639

ATP + H(2)O = ADP + phosphate.

-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).

UniProtKB Entries (1)

P32639

BRR2_YEAST

Saccharomyces cerevisiae S288C

Pre-mRNA-splicing helicase BRR2

PDB Structure

PDB	3HIB
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2. Zhang, L., Xu, T., Maeder, C., Bud, L.O., Shanks, J., Nix, J., Guthrie, C., Pleiss, J.A., Zhao, R. Nat.Struct.Mol.Biol.