CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.540 | Radical SAM ThiC family, central domain |
Domain Context
CATH Clusters
| Superfamily | Radical SAM ThiC family, central domain |
| Functional Family | Phosphomethylpyrimidine synthase |
Enzyme Information
| 4.1.99.17 |
Phosphomethylpyrimidine synthase.
based on mapping to UniProt Q9A6Q5
5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphomethyl)pyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO.
-!- Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. -!- The first stage of catalysis is reduction of the S-adenosyl-L- methionine to produce L-methionine and a 5'-deoxyadenosin-5'-yl radical that is crucial for the conversion of the substrate. -!- Part of the pathway for thiamine biosynthesis.
|
UniProtKB Entries (1)
| Q9A6Q5 |
THIC_CAUVC
Caulobacter vibrioides CB15
Phosphomethylpyrimidine synthase
|
PDB Structure
| PDB | 3EPO |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily
Nat.Chem.Biol.
|
