CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.30 | Luciferase-like domain |
Domain Context
CATH Clusters
| Superfamily | Luciferase-like domain |
| Functional Family | F420-dependent glucose-6-phosphate dehydrogenase |
Enzyme Information
| 1.1.98.2 |
Glucose-6-phosphate dehydrogenase (coenzyme-F420).
based on mapping to UniProt P9WNE1
D-glucose 6-phosphate + oxidized coenzyme F420 = D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420.
-!- The enzyme is very specific for D-glucose 6-phosphate. -!- No activity with NAD(+), NADP(+), flavin adenine dinucleotide and flavin mononucleotide. -!- Formerly EC 1.1.99.34.
|
UniProtKB Entries (1)
| P9WNE1 |
FGD_MYCTU
Mycobacterium tuberculosis H37Rv
F420-dependent glucose-6-phosphate dehydrogenase
|
PDB Structure
| PDB | 3C8N |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Mycobacterium |
| Primary Citation |
Crystal structures of F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824 reveal the basis of coenzyme and substrate binding.
J.Biol.Chem.
|
