CATH Domain 2xx4A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.565	Heat Shock Protein 90
	3.30.565.10	Histidine kinase-like ATPase, C-terminal domain

Domain Context

CATH Clusters

Superfamily	Histidine kinase-like ATPase, C-terminal domain
Functional Family	Heat shock protein HSP 90-alpha

Enzyme Information

UniProtKB Entries (1)

HSP82_YEAST

Saccharomyces cerevisiae S288C

ATP-dependent molecular chaperone HSP82

PDB Structure

PDB	2XX4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Targeting the Hsp90 Molecular Chaperone with Novel Macrolactams. Synthesis, Structural, Binding, and Cellular Studies. Day, J.E., Sharp, S.Y., Rowlands, M.G., Aherne, W., Hayes, A., Raynaud, F.I., Lewis, W., Roe, S.M., Prodromou, C., Pearl, L.H., Workman, P., Moody, C.J. Acs Chem.Biol.