CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.140 | Butyryl-CoA Dehydrogenase, subunit A; domain 3 |
|
1.20.140.10 | Butyryl-CoA Dehydrogenase, subunit A, domain 3 |
Domain Context
CATH Clusters
| Superfamily | Butyryl-CoA Dehydrogenase, subunit A, domain 3 |
| Functional Family |
Enzyme Information
| 1.14.14.12 |
3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase.
based on mapping to UniProt Q0S811
3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH(2) + O(2) = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(2)O.
-!- This bacterial enzyme participates in the degradation of several steroids, including cholesterol and testosterone. -!- It can use either FADH or FMNH(2) as flavin cofactor. -!- The enzyme forms a two-component system with a reductase (HsaB) that utilizes NADH to reduce the flavin, which is then transferred to the oxygenase subunit.
|
UniProtKB Entries (1)
| Q0S811 |
HSAA_RHOJR
Rhodococcus jostii RHA1
Flavin-dependent monooxygenase, oxygenase subunit HsaA
|
PDB Structure
| PDB | 2RFQ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of 3-HSA hydroxylase, oxygenase from Rhodococcus sp. RHA1.
To be Published
|
