CATH Domain 2nzxB02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.11650	Glycosyl transferase family 10, N-terminal domain

Domain Context

CATH Clusters

Superfamily	Glycosyl transferase family 10, N-terminal domain
Functional Family

Enzyme Information

2.4.1.152

4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase.

based on mapping to UniProt O30511

GDP-beta-L-fucose + (1->4)-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R = GDP + (1->4)-beta-D-galactosyl-(alpha-(1->3)-L-fucosyl)-N-acetyl-D- glucosaminyl-R.

-!- Normally acts on a glycoconjugate where R (see CA line) is a glycoprotein or glycolipid. -!- This enzyme fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4, unlike EC 2.4.1.65, which fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3.

UniProtKB Entries (1)

O30511

FUCT_HELPX

Helicobacter pylori

Alpha-(1,3)-fucosyltransferase FucT

PDB Structure

PDB	2NZX
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structure and mechanism of Helicobacter pylori fucosyltransferase. A basis for lipopolysaccharide variation and inhibitor design. Sun, H.Y., Lin, S.W., Ko, T.P., Pan, J.F., Liu, C.L., Lin, C.N., Wang, A.H., Lin, C.H. J. Biol. Chem.