CATH Domain 2l3cA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.160	Double Stranded RNA Binding Domain
	3.30.160.20

Domain Context

CATH Clusters

Superfamily	3.30.160.20
Functional Family	Adenosine deaminase RNA-specific B2 (inactive)

Enzyme Information

3.5.4.37

Double-stranded RNA adenine deaminase.

based on mapping to UniProt P51400

Adenine in double-stranded RNA + H(2)O = hypoxanthine in double-stranded RNA + NH(3).

-!- This eukaryotic enzyme is involved in RNA editing. -!- It destabilizes double-stranded RNA through conversion of adenosine to inosine. -!- Inositol hexakisphosphate is required for activity.

UniProtKB Entries (1)

P51400

RED1_RAT

Rattus norvegicus

Double-stranded RNA-specific editase 1

PDB Structure

PDB	2L3C
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism
Primary Citation	The Solution Structure of the ADAR2 dsRBM-RNA Complex Reveals a Sequence-Specific Readout of the Minor Groove. Stefl, R., Oberstrass, F.C., Hood, J.L., Jourdan, M., Zimmermann, M., Skrisovska, L., Maris, C., Peng, L., Hofr, C., Emeson, R.B., Allain, F.H. Cell(Cambridge,Mass.)