CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.300 | P-loop containing nucleotide triphosphate hydrolases |
Domain Context
CATH Clusters
| Superfamily | P-loop containing nucleotide triphosphate hydrolases |
| Functional Family | Large T antigen |
Enzyme Information
| 3.6.4.- |
Acting on ATP; involved in cellular and subcellular movement.
based on mapping to UniProt P03070
|
UniProtKB Entries (2)
| P03070 |
LT_SV40
Macaca mulatta polyomavirus 1
Large T antigen
|
| P04637 |
P53_HUMAN
Homo sapiens
Cellular tumor antigen p53
|
PDB Structure
| PDB | 2H1L |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of SV40 large T-antigen bound to p53: interplay between a viral oncoprotein and a cellular tumor suppressor.
Genes Dev.
|
