CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.405 | Guanine Nucleotide Dissociation Inhibitor; domain 1 |
|
1.10.405.10 | Guanine Nucleotide Dissociation Inhibitor, domain 1 |
Domain Context
CATH Clusters
| Superfamily | Guanine Nucleotide Dissociation Inhibitor, domain 1 |
| Functional Family | Amine oxidase [flavin-containing] |
Enzyme Information
| 1.4.3.4 |
Monoamine oxidase.
based on mapping to UniProt P21397
RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2).
-!- Catalyzes the oxidative deamination of neurotransmitters and biogenic amines. -!- Acts on primary amines, and also on some secondary and tertiary amines. -!- It differs from EC 1.4.3.21, as it can oxidize secondary and tertiary amines but not methylamine. -!- Inhibited by acetylenic compounds such as chlorgyline, 1-deprenyl and pargyline but, unlike EC 1.4.3.21 and EC 1.4.3.22, it is not inhibited by semicarbazide. -!- Formerly EC 1.4.3.9.
|
UniProtKB Entries (1)
| P21397 |
AOFA_HUMAN
Homo sapiens
Amine oxidase [flavin-containing] A
|
PDB Structure
| PDB | 2BXR |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Three-Dimensional Structure of Human Monoamine Oxidase a (Mao A): Relation to the Structures of Rat Mao a and Human Mao B
Proc.Natl.Acad.Sci.USA
|
