CATH Domain 1zy1A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.45	Peptide Deformylase
	3.90.45.10	Peptide deformylase

Domain Context

CATH Clusters

Superfamily	Peptide deformylase
Functional Family	Peptide deformylase

Enzyme Information

3.5.1.88

Peptide deformylase.

based on mapping to UniProt Q9FV53

Formyl-L-methionyl peptide + H(2)O = formate + methionyl peptide.

-!- Requires at least a dipeptide for an efficient rate of reaction. -!- N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. -!- Differs in substrate specificity from EC 3.5.1.27 and EC 3.5.1.31.

UniProtKB Entries (1)

Q9FV53

DEF1A_ARATH

Arabidopsis thaliana

Peptide deformylase 1A, chloroplastic/mitochondrial

PDB Structure

PDB	1ZY1
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	The crystal structure of mitochondrial (Type 1A) peptide deformylase provides clear guidelines for the design of inhibitors specific for the bacterial forms Fieulaine, S., Juillan-Binard, C., Serero, A., Dardel, F., Giglione, C., Meinnel, T., Ferrer, J.-L. J.Biol.Chem.