CATH Classification
Domain Context
CATH Clusters
Superfamily | 2.40.50.100 |
Functional Family |
Enzyme Information
2.7.7.6 |
DNA-directed RNA polymerase.
based on mapping to UniProt Q9KWU7
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.
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UniProtKB Entries (1)
Q9KWU8 |
RPOA_THEAQ
Thermus aquaticus
DNA-directed RNA polymerase subunit alpha
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PDB Structure
PDB | 1YNJ |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase
Embo J.
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