CATH Domain 1y7vA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.80	Glycosidases

Domain Context

CATH Clusters

Superfamily	Glycosidases
Functional Family	Lysosomal acid glucosylceramidase

Enzyme Information

2.4.1.-	Hexosyltransferases. based on mapping to UniProt P04062
3.2.1.104	Steryl-beta-glucosidase. based on mapping to UniProt P04062 Cholesteryl-beta-D-glucoside + H(2)O = D-glucose + cholesterol. -!- Acts on glucosides of cholesterol and sitosterol, but not on some related sterols such as coprostanol.
3.2.1.45	Glucosylceramidase. based on mapping to UniProt P04062 D-glucosyl-N-acylsphingosine + H(2)O = D-glucose + N-acylsphingosine. -!- Also acts on glucosylsphingosine (cf. EC 3.2.1.62).

UniProtKB Entries (1)

GLCM_HUMAN

Homo sapiens

Lysosomal acid glucosylceramidase

PDB Structure

PDB	1Y7V
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Cricetulus
Primary Citation	X-ray structure of human acid-beta-glucosidase covalently bound to conduritol-B-epoxide. Implications for Gaucher disease. Premkumar, L., Sawkar, A.R., Boldin-Adamsky, S., Toker, L., Silman, I., Kelly, J.W., Futerman, A.H., Sussman, J.L. J.Biol.Chem.