CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.70 | Alpha-Beta Plaits |
|
3.30.70.1230 | Nucleotide cyclase |
Domain Context
CATH Clusters
| Superfamily | Nucleotide cyclase |
| Functional Family | pH-sensitive adenylate cyclase Rv1264 |
Enzyme Information
| 4.6.1.1 |
Adenylate cyclase.
based on mapping to UniProt P9WMU9
ATP = 3',5'-cyclic AMP + diphosphate.
-!- Also acts on dATP to form 3',5'-cyclic dAMP. -!- Requires pyruvate. -!- Activated by NAD(+) in presence of EC 2.4.2.31.
|
UniProtKB Entries (1)
| P9WMU9 |
Y1264_MYCTU
Mycobacterium tuberculosis H37Rv
PH-sensitive adenylate cyclase Rv1264
|
PDB Structure
| PDB | 1Y10 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
The structure of a pH-sensing mycobacterial adenylyl cyclase holoenzyme
Science
|
