CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.1210 | Type Iii Antifreeze Protein Isoform Hplc 12 |
|
3.90.1210.10 | Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain |
Domain Context
CATH Clusters
| Superfamily | Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain |
| Functional Family | Sialic acid synthase |
Enzyme Information
| 2.5.1.57 |
N-acylneuraminate-9-phosphate synthase.
based on mapping to UniProt Q9NR45
Phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate + H(2)O = N-acylneuraminate 9-phosphate + phosphate.
-!- Acts on N-glycoloyl and N-acetyl-derivatives. -!- Formerly EC 4.1.3.20.
|
| 2.5.1.56 |
N-acetylneuraminate synthase.
based on mapping to UniProt Q9NR45
Phosphoenolpyruvate + N-acetyl-D-mannosamine + H(2)O = phosphate + N-acetylneuraminate.
-!- Formerly EC 4.1.3.19.
|
UniProtKB Entries (1)
| Q9NR45 |
SIAS_HUMAN
Homo sapiens
Sialic acid synthase
|
PDB Structure
| PDB | 1WVO |
| External Links | |
| Method | SOLUTION NMR |
| Organism | |
| Primary Citation |
Solution structure of the antifreeze-like domain of human sialic acid synthase
Protein Sci.
|
