CATH Classification

Domain Context

CATH Clusters

Superfamily Iron/manganese superoxide dismutase, C-terminal domain
Functional Family Superoxide dismutase [Mn], mitochondrial

Enzyme Information

1.15.1.1
Superoxide dismutase.
based on mapping to UniProt P04179
2 superoxide + 2 H(+) = O(2) + H(2)O(2).

UniProtKB Entries (1)

P04179
SODM_HUMAN
Homo sapiens
Superoxide dismutase [Mn], mitochondrial

PDB Structure

PDB 1VAR
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Human mitochondrial manganese superoxide dismutase polymorphic variant Ile58Thr reduces activity by destabilizing the tetrameric interface.
Borgstahl, G.E., Parge, H.E., Hickey, M.J., Johnson, M.J., Boissinot, M., Hallewell, R.A., Lepock, J.R., Cabelli, D.E., Tainer, J.A.
Biochemistry
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