CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.287 | Helix Hairpins |
|
1.10.287.990 | Fe,Mn superoxide dismutase (SOD) domain |
Domain Context
CATH Clusters
| Superfamily | Fe,Mn superoxide dismutase (SOD) domain |
| Functional Family | Superoxide dismutase |
Enzyme Information
| 1.15.1.1 |
Superoxide dismutase.
based on mapping to UniProt P04179
2 superoxide + 2 H(+) = O(2) + H(2)O(2).
|
UniProtKB Entries (1)
| P04179 |
SODM_HUMAN
Homo sapiens
Superoxide dismutase [Mn], mitochondrial
|
PDB Structure
| PDB | 1VAR |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Human mitochondrial manganese superoxide dismutase polymorphic variant Ile58Thr reduces activity by destabilizing the tetrameric interface.
Biochemistry
|
