CATH Domain 1rjgA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.150	Vaccinia Virus protein VP39

Domain Context

CATH Clusters

Superfamily	Vaccinia Virus protein VP39
Functional Family

Enzyme Information

2.1.1.233

[Phosphatase 2A protein]-leucine-carboxy methyltransferase.

based on mapping to UniProt Q04081

S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine = S-adenosyl- L-homocysteine + [phosphatase 2A protein]-leucine methyl ester.

-!- Methylates the C-terminal leucine of phosphatase 2A. -!- A key regulator of protein phosphatase 2A. -!- The methyl ester is hydrolyzed by EC 3.1.1.89. -!- Occurs mainly in the cytoplasm, Golgi region and late endosomes.

UniProtKB Entries (1)

Q04081

LCMT1_YEAST

Saccharomyces cerevisiae S288C

Leucine carboxyl methyltransferase 1

PDB Structure

PDB	1RJG
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structure of protein phosphatase methyltransferase 1 (PPM1), a leucine carboxyl methyltransferase involved in the regulation of protein phosphatase 2A activity Leulliot, N., Quevillon-Cheruel, S., Sorel, I., Li de La Sierra-Gallay, I., Collinet, B., Graille, M., Blondeau, K., Bettache, N., Poupon, A., Janin, J., van Tilbeurgh, H. J.Biol.Chem.