CATH Domain 1qqtA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.620	HUPs

Domain Context

CATH Clusters

Superfamily	HUPs
Functional Family	Methionine--tRNA ligase

Enzyme Information

6.1.1.10

Methionine--tRNA ligase.

based on mapping to UniProt P00959

ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl- tRNA(Met).

-!- In those organisms producing N-formylmethionyl-tRNA(fMet) for translation initiation, this enzyme also recognizes the initiator tRNA(fMet) and catalyzes the formation of L-methionyl-tRNA(fMet), the substrate for EC 2.1.2.9.

UniProtKB Entries (1)

P00959

SYM_ECOLI

Escherichia coli K-12

Methionine--tRNA ligase

PDB Structure

PDB	1QQT
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of Escherichia coli methionyl-tRNA synthetase highlights species-specific features. Mechulam, Y., Schmitt, E., Maveyraud, L., Zelwer, C., Nureki, O., Yokoyama, S., Konno, M., Blanquet, S. J.Mol.Biol.