CATH Domain 1nd2C00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.120	Jelly Rolls
	2.60.120.20

Domain Context

CATH Clusters

Superfamily	2.60.120.20
Functional Family	Genome polyprotein

Enzyme Information

3.4.22.29	Picornain 2A. based on mapping to UniProt Q82122 Selective cleavage of Tyr-\|-Gly bond in the picornavirus polyprotein. -!- From entero- and rhinoviruses. -!- Smaller than the homologous virus picornain 3C. -!- Belongs to peptidase family C3.
3.4.22.28	Picornain 3C. based on mapping to UniProt Q82122 Selective cleavage of Gln-\|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly. -!- From entero-, rhino-, aphto- and cardioviruses. -!- Larger than the homologous virus picornain 2A. -!- Belongs to peptidase family C3.
2.7.7.48	RNA-directed RNA polymerase. based on mapping to UniProt Q82122 Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). -!- Catalyzes RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- See also EC 2.7.7.6.
3.6.1.15	Nucleoside-triphosphate phosphatase. based on mapping to UniProt Q82122 NTP + H(2)O = NDP + phosphate. -!- The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria. -!- Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD. -!- The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.

UniProtKB Entries (1)

POLG_HRV16

Human rhinovirus A16

Genome polyprotein

PDB Structure

PDB	1ND2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural and virological studies of the stages of virus replication that are affected by antirhinovirus compounds Zhang, Y., Simpson, A.A., Ledford, R.M., Bator, C.M., Chakravarty, S., Skochko, G.A., Demenczuk, T.M., Watanyar, A., Pevear, D.C., Rossmann, M.G. J.Virol.